The choice of RV and its optimal dosage should be determined by the quantity and bioavailability of the contained iron, portability, cost. It should be borne in mind that an adequate increase in hemoglobin in patients with IDA may be achieved by intake of 30 to 100 mg of elemental iron. Given that the development of IDA iron absorption is increased compared to the norm and is 25-30% (with normal iron stores - only 3-7%), it is necessary to assign 100 to 300 mg of elemental iron per day. The use of higher doses has no meaning, since iron absorption is not increased. With this in mind when choosing a RV should be guided not by their content of total iron compounds, and the amount of elemental iron. For example, administration of these drugs ferrous sulfate with a low content of elemental iron (less than 100 mg), the number of tablets taken must be 3 or higher (depending on the content of iron in each pill), while drugs sulfate, fumarate or gidroksipolimaltoznogo iron complex with containing 100 mg elemental iron can be taken in an amount of 1-2 tablets per day.
The main PSG are iron sulfate, gluconate, chloride, fumarate, glycine sulfate. The greatest brand name viagra degree of absorption of drugs have iron sulfate, and the smallest - glycine sulphate. Many of the PSG contain substances such as ascorbic acid, reinforcing iron absorption and improve bioavailability, as well as vitamins (folic acid, cyanocobalamin). Among the VLS in the domestic market are gidroksipolimaltozny complex, iron-sorbitolovy complex protein suktsinilat iron, iron-sucrose complex. The new highly effective and safe iron preparations are preparations which are non-ionic compound of iron-based gidroksipolimaltoznogo Complex (GIC) of ferric iron.
The structure of the complex consists of a multi-center hydroxide Fe (III), surrounded by non-covalently bound molecules polymaltose. The complex has a large molecular weight, which hinders its diffusion through the membrane of the intestinal mucosa. Chemical structure of the complex is as close to the structure of natural compounds of iron with ferritin. Absorption of iron in the form of GIC has a fundamentally different scheme than its ionic compounds and ensures the supply of Fe (III) from the intestine into the blood by active suction. Nonionic structure of the complex ensures its stability and transport of iron by the transport protein in the body that prevents free diffusion of iron ions, ie prooxidant reactions.
Safety data collected during clinical trials of the drug on the basis of iron hydroxide Fe (III) with polymaltose indicate a low incidence of side effects compared with the salt with iron. For better portability PSG should be taken with food, although it should be borne in mind that iron absorption is better when Viagra cost per pill taking medication before eating. Vsasyvaniezheleza may decrease under the influence contained in certain food substances - phytin (rice, soy), phosphate (fish, seafood), tannins (tea, coffee).
Many patients tend to wash down medicines, we conclude that in cases receiving the pancreas in the form of salt is unacceptable because the formation of poorly soluble complexes with their low absorption in the intestine. In addition, the absorption of iron from the pancreas in the form of salts deteriorates while receiving several medications (tetracyclines, antacids, magnesium salts). With this in mind to recommend supplementation of iron salts at different times with the other above-mentioned drugs. Preparations VLS in particular gidroksipolimaltozny complex devoid of such shortcomings, because Food and Drug Administration does not affect the absorbability of iron (as the trivalent form) of the iron complexes. Table 2 shows the main drugs registered in Russia, PSG and VLC for ingestion.
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